Concentrations of Gd-BOPTA in cholestatic fatty rat livers: role of transport functions through membrane proteins
نویسندگان
چکیده
منابع مشابه
Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers.
OBJECTIVE To quantify the hepatic transport of the hepatobiliary contrast agent gadobenate dimeglumine (Gd-BOPTA) in rats with biliary cirrhosis of various severity degrees from magnetic resonance (MR) signal intensities using a population pharmacokinetic approach. MATERIALS AND METHODS MR signal intensity was recorded during the Gd-BOPTA perfusion of normal and cirrhotic isolated rat livers....
متن کاملDirect evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver.
The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR s...
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OBJECTIVES We sought to develop and validate a pharmacokinetic model allowing description of the magnetic resonance (MR) signal intensity induced by the hepatobiliary contrast agent Gd-BOPTA and to quantify the overall Gd-BOPTA transport in rat liver. MATERIALS AND METHODS MR signal intensity was recorded during the perfusion of rat livers with Gd-DTPA, an extracellular contrast agent, and Gd...
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ژورنال
عنوان ژورنال: Contrast Media & Molecular Imaging
سال: 2012
ISSN: 1555-4309
DOI: 10.1002/cmmi.1511